Unilateral lower limb suspension: From subject selection to “omic” responses
نویسندگان
چکیده
منابع مشابه
Unilateral lower limb suspension can cause deep venous thrombosis.
To the Editor: We would like to bring to your attention and to the attention of the scientific community that unilateral lower limb suspension (ULLS), a model for physical inactivity and simulating microgravity unloading in humans, is associated with an increased risk of deep venous thrombosis (DVT). In the ULLS model, which was originally developed by Berg et al. (2), subjects use crutches for...
متن کاملVascular adaptation to 4 wk of deconditioning by unilateral lower limb suspension.
Physical inactivity or deconditioning is an independent risk factor for atherosclerosis and cardiovascular disease. In contrast to exercise, the vascular changes that occur as a result of deconditioning have not been characterized. We used 4 wk of unilateral lower limb suspension (ULLS) to study arterial and venous adaptations to deconditioning. In contrast to previous studies, this model is no...
متن کاملOxygen uptake kinetics following 20 days of unilateral lower limb suspension.
The purpose of the present study was to examine the effect of unilateral lower limb suspension (ULLS) deconditioning on oxygen uptake kinetics. Eight healthy males underwent ULLS for 20 days and performed a series of 6-min square-wave transitions from rest to 60-W single-leg cycling exercises just before and after ULLS. To characterize the kinetics of the oxygen uptake response, a single expone...
متن کاملUnilateral lower limb suspension does not mimic bed rest or spaceflight effects on human muscle fiber function.
We used Ca2+-activated skinned muscle fibers to test the hypothesis that unilateral lower leg suspension (ULLS) alters cross-bridge mechanisms of muscle contraction. Soleus and gastrocnemius biopsies were obtained from eight subjects before ULLS, immediately after 12 days of ULLS (post-0 h), and after 6 h of reambulation (post-6 h). Post-0 h soleus fibers expressing type I myosin heavy chain (M...
متن کاملA foot care program for diabetic unilateral lower-limb amputees.
OBJECTIVE To assess the efficacy of a specialist foot care program designed to prevent a second amputation and to assess peripheral vascular disease (PVD) and peripheral neuropathy in diabetic unilateral lower-limb amputees. RESEARCH DESIGN AND METHODS Investigations were carried out in 143 diabetic lower-limb unilateral amputees referred to a subregional rehabilitation center for prosthetic ...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2016
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.01052.2015